日本人群中儿茶酚-O-甲基转移酶基因多态性与子宫肌瘤的关联研究。
Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population.
作者信息
Morikawa J, Yoshida S, Kennedy S, Takemura N, Sugimoto M, Kitao K, Deguchi M, Ohara N, Maruo T
机构信息
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
Clin Exp Obstet Gynecol. 2008;35(1):35-40.
PURPOSE
To investigate a possible association between uterine leiomyomas and catechol-O-methyltransferase (COMT) polymorphisms in a Japanese population.
METHODS
We compared the allele frequencies and genotype distributions of the exon 4 NlaIII restriction site polymorphism (RSP), the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP in the COMT gene in 250 leiomyoma cases and 182 controls using polymerase chain reaction-restriction fragment-length polymorphism analysis.
RESULTS
No significant differences in allele frequencies and genotype distributions of the exon 4 NlaIII RSP, the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP were found between uterine leiomyoma cases and controls. Moreover, no associations were noted between these three polymorphisms in COMT genes and leiomyoma size or a family history of uterine leiomyomas.
CONCLUSION
COMT gene polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in a Japanese population.
目的
在日本人群中研究子宫平滑肌瘤与儿茶酚-O-甲基转移酶（COMT）基因多态性之间可能存在的关联。
方法
我们采用聚合酶链反应-限制性片段长度多态性分析，比较了250例平滑肌瘤病例和182例对照中COMT基因第4外显子NlaIII限制性位点多态性（RSP）、-1217处P2启动子HindIII RSP以及第6外显子BglI RSP的等位基因频率和基因型分布。
结果
子宫平滑肌瘤病例与对照之间，第4外显子NlaIII RSP、-1217处P2启动子HindIII RSP以及第6外显子BglI RSP的等位基因频率和基因型分布无显著差异。此外，COMT基因的这三种多态性与平滑肌瘤大小或子宫平滑肌瘤家族史之间未发现关联。
结论
在日本人群中，COMT基因多态性不太可能与子宫平滑肌瘤风险增加相关。
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