中国女性中CYP1A1和CYP1B1基因多态性与子宫肌瘤风险
CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.
作者信息
Ye Yi, Cheng Xiao, Luo Hai-Bo, Liu Li, Li Ying-Bi, Hou Yi-Ping
机构信息
Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan, China.
出版信息
J Assist Reprod Genet. 2008 Aug;25(8):389-94. doi: 10.1007/s10815-008-9246-x. Epub 2008 Sep 2.
Abstract
PURPOSE
The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese women.
METHODS
We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women. The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were analyzed by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing method.
RESULTS
All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different between uterine leiomyoma patients and controls (P < 0.05).
CONCLUSION
These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.
摘要
目的
本研究旨在评估中国女性中CYP1A1和CYP1B1基因多态性与子宫肌瘤的相关性。
方法
我们调查了100例临床诊断为子宫肌瘤的中国女性以及110例健康正常受试者。采用聚合酶链反应-限制性片段长度多态性和DNA测序方法分析了CYP1A1基因MspI位点Ile462Val的两个多态性以及CYP1B1基因Arg48Gly、Ala119Ser、Leu432Val、Asp449Asp的四个多态性的基因分布。
结果
所有单核苷酸多态性在中国女性中均表现出多态性。子宫肌瘤患者和对照组在Ile462Val位点的基因型A/G和等位基因G存在显著差异（P < 0.05）。
结论
这些结果表明，CYP1A1基因Ile462Val的基因型与中国女性子宫肌瘤风险增加相关。
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