海马体CA1区和CA3区在消退性恐惧的情境编码与提取中的不同作用。
Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear.
作者信息
Ji Jinzhao, Maren Stephen
机构信息
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109-1043, USA.
出版信息
Learn Mem. 2008 Apr 3;15(4):244-51. doi: 10.1101/lm.794808. Print 2008 Apr.
Recent studies demonstrate that context-specific memory retrieval after extinction requires the hippocampus. However, the contribution of hippocampal subfields to the context-dependent expression of extinction is not known. In the present experiments, we examined the roles of areas CA1 and CA3 of the dorsal hippocampus in the context specificity of extinction. After pairing an auditory conditional stimulus (CS) with an aversive footshock (unconditional stimulus or US), rats received extinction sessions in which the CS was presented without the US. In Experiment 1, pretraining neurotoxic lesions in either CA1 or CA3 eliminated the context dependence of extinguished fear. In Experiment 2, lesions of CA1 or CA3 were made after extinction training. In this case, only CA1 lesions impaired the context dependence of extinction. Collectively, these results reveal that both hippocampal areas CA1 and CA3 contribute to the acquisition of context-dependent extinction, but that only area CA1 is required for contextual memory retrieval.
近期研究表明，消退后特定情境的记忆提取需要海马体。然而，海马体亚区对消退的情境依赖性表达的贡献尚不清楚。在本实验中，我们研究了背侧海马体CA1区和CA3区在消退的情境特异性中的作用。在将听觉条件刺激（CS）与厌恶性足部电击（无条件刺激或US）配对后，大鼠接受消退训练，在此期间呈现CS但不给予US。在实验1中，CA1区或CA3区的训练前神经毒性损伤消除了消退恐惧的情境依赖性。在实验2中，在消退训练后对CA1区或CA3区进行损伤。在这种情况下，只有CA1区损伤损害了消退的情境依赖性。总体而言，这些结果表明，海马体CA1区和CA3区都有助于获得情境依赖性消退，但只有CA1区是情境记忆提取所必需的。
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