有氧间歇训练可增强心肌肌浆网Ca2+ ATP酶的功能。
Myocardial sarcoplasmic reticulum Ca2+ ATPase function is increased by aerobic interval training.
作者信息
Kemi Ole Johan, Ceci Marcello, Condorelli Gianluigi, Smith Godfrey L, Wisloff Ulrik
机构信息
Institute of Biomedical and Life Sciences, University of Glasgow, UK.
出版信息
Eur J Cardiovasc Prev Rehabil. 2008 Apr;15(2):145-8. doi: 10.1097/HJR.0b013e3282efd4e0.
OBJECTIVE
Reduced activity of the sarcoplasmic reticulum Ca ATPase-2a (SERCA-2a) contributes to myocardial dysfunction. Exercise training improves myocardial Ca-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training.
METHODS
SERCA-2a function was assessed by sarcoplasmic reticulum Ca uptake in cardiomyocytes with other Ca uptake mechanisms blocked, in mice after aerobic interval training versus sedentary controls.
RESULTS
We established protocols to assess SERCA-2a function, and show that aerobic interval training increases the maximal rate of Ca uptake by 30%. This is at least partly explained by reduced phospholamban-to-SERCA-2a ratio.
CONCLUSION
Aerobic interval training improves myocardial SERCA-2a performance, explaining at least partly why myocardial Ca-handling improves after exercise training.
目的
肌浆网Ca-ATP酶-2a（SERCA-2a）活性降低会导致心肌功能障碍。运动训练可改善心肌钙处理能力，但SERCA-2a的功能尚不确定。我们评估了运动训练后SERCA-2a的活性。
方法
在有氧间歇训练小鼠与久坐对照小鼠中，通过阻断其他钙摄取机制后心肌细胞中的肌浆网钙摄取来评估SERCA-2a的功能。
结果
我们建立了评估SERCA-2a功能的方案，并表明有氧间歇训练可使最大钙摄取率提高30%。这至少部分是由于受磷蛋白与SERCA-2a的比例降低所致。
结论
有氧间歇训练可改善心肌SERCA-2a的性能，这至少部分解释了运动训练后心肌钙处理能力改善的原因。
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