Kamei J, Mori T, Igarashi H, Kasuya Y
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Eur J Pharmacol. 1991 Oct 15;203(2):253-8. doi: 10.1016/0014-2999(91)90721-2.
The effects of the agonist of 5-HT1A receptors, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), on the capsaicin-induced cough reflex in rats were studied. I.p. injection of 8-OH-DPAT, at doses of 0.1 and 0.3 mg/kg, significantly decreased the number of coughs in a dose-dependent manner. The antitussive effect of 8-OH-DPAT (0.3 mg/kg) was blocked by prior injection of methysergide (3 mg/kg i.p.) and spiperone (0.3 mg/kg i.p.), whereas ketanserin (3 mg/kg i.p.) had no effect on the antitussive effect of 8-OH-DPAT. The antitussive effects of dihydrocodeine (1 mg/kg i.p.) and dextromethorphan (3 mg/kg i.p.) were also antagonized by methysergide and spiperone. However, these cough-depressant effects were not reduced by ketanserin. These results suggest that the antitussive action of 8-OH-DPAT may be related to the enhancement of the function of 5-HT1A receptors, and that antitussives interact with the 5-HT1A receptors.
研究了5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）对辣椒素诱导的大鼠咳嗽反射的影响。腹腔注射剂量为0.1和0.3mg/kg的8-OH-DPAT，能以剂量依赖的方式显著减少咳嗽次数。预先注射麦角新碱（3mg/kg腹腔注射）和螺哌隆（0.3mg/kg腹腔注射）可阻断8-OH-DPAT（0.3mg/kg）的镇咳作用，而酮色林（3mg/kg腹腔注射）对8-OH-DPAT的镇咳作用无影响。二氢可待因（1mg/kg腹腔注射）和右美沙芬（3mg/kg腹腔注射）的镇咳作用也被麦角新碱和螺哌隆拮抗。然而，这些镇咳作用未被酮色林减弱。这些结果表明，8-OH-DPAT的镇咳作用可能与5-羟色胺1A受体功能增强有关，且镇咳药与5-羟色胺1A受体相互作用。
