Ono H, Ono S S, Fukuda H
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Eur J Pharmacol. 1991 Oct 15;203(2):283-5. doi: 10.1016/0014-2999(91)90725-6.
5-Hydroxytryptamine (5-HT, 10 microM) increased the veratridine-evoked release of thyrotropin-releasing hormone (TRH) from spinal cord slices. This effect of 5-HT was reduced by pre-exposure of the tissue to 10 microM ketanserin and methysergide, which both have 5-HT2 antagonistic activity. A 5-HT1 agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (10 microM), reduced the release of TRH. These results imply that 5-HT released from the terminals of descending fibers modulates the release of TRH, a cotransmitter contained in 5-HT fibers.
5-羟色胺（5-HT，10微摩尔）增加了藜芦碱诱发的脊髓切片中促甲状腺激素释放激素（TRH）的释放。5-HT的这种作用在组织预先暴露于10微摩尔酮色林和麦角酰二乙胺后减弱，这两种物质都具有5-HT2拮抗活性。一种5-HT1激动剂，8-羟基-2-（二正丙基氨基）四氢萘（10微摩尔），减少了TRH的释放。这些结果表明，从下行纤维终末释放的5-HT调节TRH的释放，TRH是5-HT纤维中所含的一种共递质。
