布朗斯特酸催化的硝基烷烃活化：直接对映选择性氮杂亨利反应
Brønsted-acid-catalyzed activation of nitroalkanes: a direct enantioselective aza-Henry reaction.
作者信息
Rueping Magnus, Antonchick Andrey P
机构信息
Institute of Organic Chemistry and Chemical Biology, University Frankfurt, Frankfurt am Main, Germany.
出版信息
Org Lett. 2008 May 1;10(9):1731-4. doi: 10.1021/ol8003589. Epub 2008 Apr 8.
PMID:18393508
Abstract
A direct asymmetric organocatalytic aza-Henry reaction has been developed in which a new bifunctional Brønsted-acid-catalyzed activation of nitroalkanes provides an efficient access to alpha,beta-diamino acids with high dia- and enantioselectivities under mild and base-free reaction conditions.
摘要
已开发出一种直接的不对称有机催化氮杂-Henry反应，其中一种新型双功能布朗斯特酸催化的硝基烷烃活化反应，能在温和且无碱的反应条件下，以高非对映选择性和对映选择性高效合成α,β-二氨基酸。
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