不对称布朗斯特酸催化的羰基活化-有机催化的串联电环化-卤化反应。
Asymmetric Brønsted acid catalyzed carbonyl activation--organocatalytic domino electrocyclization-halogenation reaction.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.
出版信息
Chem Commun (Camb). 2011 Nov 7;47(41):11450-2. doi: 10.1039/c1cc15289k. Epub 2011 Sep 5.
PMID:21892501
Abstract
A highly efficient Brønsted acid catalyzed enantioselective Nazarov cyclization-bromination reaction has been developed. The protocol gives access to highly functionalized trans-4,5-substituted 5-bromocyclopentenone derivatives in good yields and with excellent enantioselectivities.
摘要
发展了一种高效的布朗斯特酸催化的对映选择性 Nazarov 环化-溴化反应。该方案以良好的收率和优异的对映选择性获得了高官能化的反式 4,5-取代的 5-溴环戊烯酮衍生物。
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