Huang Fang, Wang Xiao-li, Yang Lian, Yin Bin-xia, Geng Yan, Li Ting-ting
The Department of Clinical Laboratory Diagnosis, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Apr;24(4):370-2.
To study the clinical value of combined determination of carcinoembryonic antigen (CEA), cytokeratin-19-fragments (CYFRA21-1) and tissue polypeptide specific antigen (TPS) levels in both serum and pleural effusion in the diagnosis of lung cancer.
The levels of CEA, CYFRA21-1 and TPS in serum and pleural effusion were measured in 78 patients with lung cancer and 45 patients with benign lung disease by using electrochemiluminescence and ELISA methods respectively.
The levels of CEA, CYFRA21-1 and TPS in pleural effusion of patients with lung cancer were much higher than those with benign lung disease (P<0.01). The levels of CEA and TPS in serum of patients with lung cancer were much higher than those with benign lung disease (P<0.05, P<0.01). It was also found that the levels of these tumor markers in pleural effusion were higher and more sensitive than those in sera, especially TPS. TPS showed the highest sensitivity in single tumor marker detection, and TPS+CYFRA21-1+ CEA showed the highest sensitivity and accuracy in combined tumor marker detection for diagnosis of lung cancer in pleural effusion.
The combined detection of CEA, CYFRA21-1 and TPS in pleural effusion showed higher sensitivity, better accuracy and higher clinical value than those in serum for diagnosis of lung cancer.
探讨联合检测血清和胸腔积液中癌胚抗原（CEA）、细胞角蛋白19片段（CYFRA21-1）和组织多肽特异性抗原（TPS）水平在肺癌诊断中的临床价值。
分别采用电化学发光法和酶联免疫吸附测定法检测78例肺癌患者及45例良性肺部疾病患者血清和胸腔积液中CEA、CYFRA21-1和TPS水平。
肺癌患者胸腔积液中CEA、CYFRA21-1和TPS水平显著高于良性肺部疾病患者（P<0.01）。肺癌患者血清中CEA和TPS水平显著高于良性肺部疾病患者（P<0.05，P<0.01）。还发现这些肿瘤标志物在胸腔积液中的水平高于血清，且更敏感，尤其是TPS。TPS在单项肿瘤标志物检测中敏感性最高，TPS+CYFRA21-1+CEA在联合肿瘤标志物检测中对胸腔积液肺癌诊断的敏感性和准确性最高。
联合检测胸腔积液中CEA、CYFRA21-1和TPS对肺癌诊断的敏感性、准确性及临床价值均高于血清检测。
