在无催化剂条件下超声辐射无溶剂合成1,4 - 二氢吡啶。
The solvent-free synthesis of 1,4-dihydropyridines under ultrasound irradiation without catalyst.
作者信息
Wang Shu-Xiang, Li Zhi-Yan, Zhang Jin-Chao, Li Ji-Tai
机构信息
Laboratory of Chemical Biology, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, PR China.
出版信息
Ultrason Sonochem. 2008 Jul;15(5):677-80. doi: 10.1016/j.ultsonch.2008.02.009. Epub 2008 Mar 4.
Abstract
The condensation of aldehydes, ethyl acetoacetate and ammonium acetate result 1,4-dihydropyridines in 82-99% yields under ultrasound irradiation without solvent and catalyst at room temperature. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields.
摘要
在室温下无溶剂、无催化剂的超声辐射条件下，醛、乙酰乙酸乙酯和乙酸铵缩合生成1,4 -二氢吡啶，产率为82 - 99%。与传统方法相比，本方法的主要优点是条件更温和、反应时间更短且产率更高。
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