白细胞介素（IL）-16基因多态性与格雷夫斯病的关联。
Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease.
作者信息
Gu Xue-Jiang, Cui Bin, Zhao Ze-Fei, Chen Hao-Yan, Li Xiao-Ying, Wang Shu, Ning Guang, Zhao Yong-Ju
机构信息
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China.
出版信息
Clin Immunol. 2008 Jun;127(3):298-302. doi: 10.1016/j.clim.2008.01.017. Epub 2008 Apr 3.
Interleukin (IL)-16 was one of the cytokines with the function of T helper cell recruitment, whose expression in the thyrocyte and orbital fibroblast of Graves' disease (GD) patients was increased. Recently association of IL-16 gene polymorphisms with autoimmune diseases had been reported. However, there was little known about the impact of IL-16 gene polymorphisms on GD. In this study, we performed a case-control association study of three tagSNPs (rs4778889-rs1131445-rs4778641) within the IL-16 gene on 258 patients with GD and 208 healthy subjects in the Chinese population. Our data showed that common IL-16 variants were associated with GD (P=0.013-0.0186) and Graves' disease associated ophthalmopathy (GO) (P=0.0033-0.041). A novel protective haplotype containing the three tagSNPs (C-T-C) was observed in association with GO (P=0.013). In conclusion, IL-16 gene was significantly associated with susceptibility to Graves' disease and Graves' disease associated ophthalmopathy in the Chinese population.
白细胞介素（IL）-16是具有招募辅助性T细胞功能的细胞因子之一，其在格雷夫斯病（GD）患者的甲状腺细胞和眼眶成纤维细胞中的表达增加。最近有报道称IL-16基因多态性与自身免疫性疾病有关。然而，关于IL-16基因多态性对GD的影响知之甚少。在本研究中，我们对中国人群中258例GD患者和208名健康受试者进行了IL-16基因内三个标签单核苷酸多态性（rs4778889-rs1131445-rs47７8641）的病例对照关联研究。我们的数据表明，常见的IL-16变异与GD（P = 0.013 - 0.0186）和格雷夫斯病相关性眼病（GO）（P = 0.0０33 - 0.041）相关。观察到一种包含这三个标签单核苷酸多态性（C-T-C）的新型保护性单倍型与GO相关（P = 0.013）。总之，在中国人群中，IL-16基因与格雷夫斯病及格雷夫斯病相关性眼病的易感性显著相关。
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