唐氏综合征患者的血清总胆固醇水平与阿尔茨海默病性痴呆
Total serum cholesterol levels and Alzheimer's dementia in patients with Down syndrome.
作者信息
Prasher V P, Airuehia E, Patel A, Haque M S
机构信息
Liverpool John Moore University, c/o Greenfields, Monyhull, Birmingham, UK.
出版信息
Int J Geriatr Psychiatry. 2008 Sep;23(9):937-42. doi: 10.1002/gps.2014.
BACKGROUND
The risk for dementia in Alzheimer's disease (DAD) in adults with Down syndrome (DS) is higher than in the general adult population. Hypercholesterolaemia has been reported as a risk factor for DAD in the general population. This study investigated the role of serum cholesterol levels in the onset of DAD in the DS population.
METHODS
This study investigated total serum cholesterol levels in 179 DS persons (with and without DAD). The possible association between Apolipoprotein E and amyloid beta1-40 and beta1-42 levels was also investigated.
RESULTS
No statistically significant association was found between total serum cholesterol levels and dementia in AD or with amyloid beta levels. However for DS adults with an apoE epsilon4 allele significantly higher serum cholesterol levels were found.
CONCLUSION
Hypercholesterolaemia is not a risk factor for DAD in persons with DS. However, DS persons with an apoE epsilon4 allele are susceptible to high serum cholesterol. Such individuals should be screened on a regular basis.
背景
唐氏综合征（DS）成人患阿尔茨海默病性痴呆（DAD）的风险高于普通成人人群。高胆固醇血症在普通人群中被报道为DAD的一个风险因素。本研究调查了血清胆固醇水平在DS人群DAD发病中的作用。
方法
本研究调查了179名DS患者（有或无DAD）的总血清胆固醇水平。还研究了载脂蛋白E与淀粉样β蛋白1-40和β1-42水平之间可能的关联。
结果
在总血清胆固醇水平与AD中的痴呆或淀粉样β蛋白水平之间未发现统计学上的显著关联。然而，对于携带载脂蛋白E ε4等位基因的DS成年人，发现其血清胆固醇水平显著更高。
结论
高胆固醇血症不是DS患者发生DAD的风险因素。然而，携带载脂蛋白E ε4等位基因的DS患者易患高血清胆固醇。应对此类个体定期进行筛查。
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