Mehta Pankaj D, Patrick Bruce A, Dalton Arthur J, Patel Bindu, Mehta Sangita P, Pirttila Tuula, Coyle Patricia K
Department of Immunology, Institute For Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
J Neuroimmunol. 2005 Jul;164(1-2):129-33. doi: 10.1016/j.jneuroim.2005.03.010.
We quantitated serum neopterin levels in Down syndrome (DS), normal controls, Alzheimer's disease, multiple sclerosis and other neurological diseases. We then analyzed the relationships with age, sex, apolipoprotein E (Apo E) phenotype, and amyloid beta protein 1-40 (Abeta40) and 1-42 (Abeta42) levels. Neopterin levels were higher in DS than all other groups. Levels in young DS (< 40 years of age) and old DS (> 41 years) were similar. There was no significant correlation between neopterin levels and age, sex, Apo E phenotype, and Abeta40 or Abeta42 levels in DS. This lack of correlation between neopterin and Abeta levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology.
我们对唐氏综合征（DS）患者、正常对照者、阿尔茨海默病患者、多发性硬化症患者及其他神经疾病患者的血清新蝶呤水平进行了定量分析。然后，我们分析了血清新蝶呤水平与年龄、性别、载脂蛋白E（Apo E）表型以及β淀粉样蛋白1-40（Abeta40）和1-42（Abeta42）水平之间的关系。DS患者的新蝶呤水平高于所有其他组。年轻DS患者（<40岁）和老年DS患者（>41岁）的新蝶呤水平相似。在DS患者中，新蝶呤水平与年龄、性别、Apo E表型以及Abeta40或Abeta42水平之间无显著相关性。新蝶呤与Abeta水平之间缺乏相关性表明，DS组中较高的新蝶呤浓度反映的是炎症细胞激活，而非阿尔茨海默病神经病理学。
