兰索拉唑口腔崩解片对CYP2C19广泛代谢者胃内pH值的早期影响。
Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers.
作者信息
Yamagishi Hatsushi, Koike Tomoyuki, Ohara Shuichi, Horii Toru, Kikuchi Ryousuke, Kobayashi Shigeyuki, Abe Yasuhiko, Iijima Katsunori, Imatani Akira, Suzuki Kaori, Hishinuma Takanori, Goto Junichi, Shimosegawa Tooru
机构信息
Division of Gastroenterology Tohoku University graduate school of medicine, 1-1 Seiryou-Machi, Aobaku, Sendai 9808574, Japan.
出版信息
World J Gastroenterol. 2008 Apr 7;14(13):2049-54. doi: 10.3748/wjg.14.2049.
AIM
To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose.
METHODS
Eight H pylori -negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was performed on the day of treatment. Blood samples were also collected after the administration of each drug.
RESULTS
LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study.
CONCLUSION
In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg.
目的
比较雷贝拉唑（RPZ；10毫克）与兰索拉唑口腔崩解片（LPZ；30毫克，每日一次）单次给药后的抑酸活性和血药浓度。
方法
将8名幽门螺杆菌阴性的细胞色素P450（CYP）2C19广泛代谢者分配接受单次口服10毫克RPZ或30毫克LPZ（每日一次）。治疗当天进行12小时胃内pH监测。每种药物给药后也采集血样。
结果
30毫克LPZ（每日一次）比10毫克RPZ导致血药浓度显著更早升高；因此，在研究的第三和第四小时，30毫克LPZ（每日一次）使中位pH显著更早升高。
结论
在幽门螺杆菌阴性的CYP2C19广泛代谢者中，30毫克LPZ（每日一次）比10毫克RPZ对胃酸分泌的抑制作用显著更快。
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