Schecter Marc G, Elidemir Okan, Heinle Jeffrey S, McKenzie Emmett D, Mallory George B
Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2008:74-9. doi: 10.1053/j.pcsu.2007.12.008.
Pediatric lung transplant was born at the University of Toronto as an extension of the pioneering work of Cooper and Patterson in adult lung transplant in the 1980s. Through the 1990s, the field of pediatric lung transplantation grew with clinical outcomes in the largest centers being comparable to those in adult lung transplantation. For children and adults, the largest obstacle to long-term survival remains chronic allograft rejection secondary to the development of bronchiolitis obliterans, for which little advancement has been made in prevention or treatment. While transplantation has become accepted therapy for end-stage lung disease in adults, pediatric lung transplant has been less widely embraced for multiple reasons, such as adolescent non-compliance and the investment required in developing freestanding pediatric lung transplant centers. Another factor limiting pediatric lung transplant has been the paucity of suitable donor lungs. In 2002, Texas Children's Hospital and the Baylor College of Medicine successfully collaborated in developing an active and successful pediatric lung transplant program. Through our own work and an international collaborative of pediatric transplant pulmonologists and surgeons, we are hoping to move the field of pediatric lung transplant out of its "adolescence" into adulthood.
小儿肺移植诞生于多伦多大学，是20世纪80年代库珀和帕特森在成人肺移植方面开创性工作的延伸。在整个20世纪90年代，小儿肺移植领域不断发展，最大型中心的临床结果与成人肺移植相当。对于儿童和成人来说，长期生存的最大障碍仍然是闭塞性细支气管炎发展导致的慢性移植物排斥反应，在预防或治疗方面进展甚微。虽然移植已成为成人终末期肺病的公认疗法，但小儿肺移植因多种原因未得到广泛接受，比如青少年不依从以及建立独立小儿肺移植中心所需的投入。限制小儿肺移植的另一个因素是合适供体肺的匮乏。2002年，德克萨斯儿童医院和贝勒医学院成功合作开展了一个活跃且成功的小儿肺移植项目。通过我们自己的工作以及小儿移植肺科医生和外科医生的国际合作，我们希望将小儿肺移植领域从其“青春期”带入成年期。
