Sharma Pratibha, Kumar Ashok, Upadhyay Siya, Sahu Vinita, Singh Jitendra
School of Chemical Sciences, Devi Ahilya University, Takshashila Campus, Indore 452 001, MP, India.
Eur J Med Chem. 2009 Jan;44(1):251-9. doi: 10.1016/j.ejmech.2008.02.016. Epub 2008 Feb 29.
The present communication deals with the synthesis of a series of 2-acetyl-2-ethoxycarbonyl-1-[4(4'-arylazo)-phenyl]-N,N-dimethylaminophenyl aziridines. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the basis of consistent IR, (1)H NMR and elemental analysis data. The purity has been ascertained by chromatographic resolution using acetic acid--toluene (6:4v/v) as binary eluent. All the compounds have been tested for their antimicrobial activity against a representative panel of bacteria i.e. Bacillus subtilis, Escherichia coli, Pseudomonas diminuta and Staphylococcus aureus using azinomycin as reference drug. All the synthesized compounds were found to exhibit profound antimicrobial activity.
本通讯报道了一系列2-乙酰基-2-乙氧羰基-1-[4-(4'-芳基偶氮)-苯基]-N,N-二甲基氨基苯基氮丙啶的合成。这些化合物的合成产率很高（70-80%），其结构是根据一致的红外光谱、¹H核磁共振光谱和元素分析数据确定的。使用乙酸-甲苯（6:4 v/v）作为二元洗脱剂通过色谱分离确定了纯度。以氮霉素为参考药物，对所有化合物针对一组代表性细菌即枯草芽孢杆菌、大肠杆菌、微小假单胞菌和金黄色葡萄球菌进行了抗菌活性测试。发现所有合成化合物均表现出显著的抗菌活性。
