Akimov Iu A, Rodionov A A, Grishchenko A I, Azhipa Ia I
Izv Akad Nauk SSSR Biol. 1991 Nov-Dec(6):897-905.
The results are presented of investigations on determining the functional state of mineralocorticoid receptor apparatus in rat kidney at diverse stages of the reflex renal dystrophy per se and that against the background of renal denervation along with propranolol injections produced at different terms following the disturbance of nervous system trophic function. It was shown that simultaneous blockade of neuroconductory and humoral pathways of pathological stimulus transmission from central end of cut ischiatic nerve to the kidney prevents the development of trophic disturbances in the organ as tested by the state of mineralocorticoid receptors, to a more extent than the blockade of neuroconductory pathway only. The activity of molecular structures which determine the mineralocorticoid reception in cells of renal tubules seems to be controlled both by central neuroconductory and humoral mechanisms.
本文呈现了关于在反射性肾营养不良本身的不同阶段以及在肾去神经支配背景下，同时注射普萘洛尔且在神经系统营养功能紊乱后的不同时期，对大鼠肾脏中盐皮质激素受体装置功能状态进行测定的研究结果。结果表明，同时阻断从坐骨神经切断端中枢到肾脏的病理刺激传递的神经传导和体液途径，相较于仅阻断神经传导途径，能在更大程度上通过盐皮质激素受体状态来预防器官营养紊乱的发生。决定肾小管细胞中盐皮质激素受体的分子结构活性似乎受中枢神经传导和体液机制的共同控制。
