Dystrophic mineralisation in cerebrum of aging mice.

The incidence of cerebral dystrophic mineralisation in CD-1 mice (Charles River bred, cesarean-derived) obtained from long term studies over a 10 year period is reported. The survey included brain samples from 15869 males and 15729 females. The incidence of cerebral dystrophic mineralisation is 0.6% in untreated males and 0.3% in untreated females. The total incidence in all mice in the survey showed higher incidence in males than females and was age-related. The present survey also showed interstrain differences. The mineralisation in CD-1 strain was low in incidence and B6C3Fl (cross between C57BL/C6 NCR LB and C3H/HEN NCR LB, bred by Charles River) with relatively high incidence. The foci of mineralisation was dystrophic and probably of neuronal origin in this survey.