癌症：干细胞程序的异常表达？

Cancer: inappropriate expression of stem cell programs?

作者信息

Wang Yingzi, Armstrong Scott A

机构信息

Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Cell Stem Cell. 2008 Apr 10;2(4):297-9. doi: 10.1016/j.stem.2008.03.014.

DOI:10.1016/j.stem.2008.03.014

PMID:18397746

Abstract

Cancer stem cells (CSCs) are a subpopulation of cancer cells that possess characteristics, including self-renewal, associated with normal stem cells. In this issue of Cell Stem Cell, Wong et al. (2008) define a core embryonic stem cell (ESC)-like gene expression program that may be important for CSC function in multiple epithelial cancers.

摘要

癌症干细胞（CSCs）是癌细胞的一个亚群，具有与正常干细胞相关的特性，包括自我更新能力。在本期《细胞干细胞》杂志中，Wong等人（2008年）定义了一个核心的胚胎干细胞（ESC）样基因表达程序，该程序可能对多种上皮癌中癌症干细胞的功能至关重要。