铜（II）与大鼠β-淀粉样蛋白（1-28）片段形成的配合物的结构特征
Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment.
作者信息
Gaggelli Elena, Grzonka Zbigniew, Kozłowski Henryk, Migliorini Caterina, Molteni Elena, Valensin Daniela, Valensin Gianni
机构信息
Department of Chemistry, University of Siena, via Aldo Moro, 53100 Siena, Italy.
出版信息
Chem Commun (Camb). 2008 Jan 21(3):341-3. doi: 10.1039/b713453c.
DOI:10.1039/b713453c
PMID:18399201
Abstract
The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.
摘要
通过圆二色光谱（CD）和核磁共振光谱（NMR）研究了pH 7.5条件下胶束溶液中铜（II）与大鼠β-淀粉样蛋白（1-28）片段之间的相互作用；质子-铜距离被用于受限分子动力学模拟，以获得铜（II）配合物的结构模型。
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