M3胆碱能受体参与大鼠心脏活动胆碱能调节的出生后发育。

M3 cholinergic receptors are involved in postnatal development of cholinergic regulation of cardiac activity in rats.

作者信息

Zefirov T L, Gibina A E, Salman M A H, Ziyatdinova N I, Zefirov A L

机构信息

Department of Anatomy, Physiology, and Human Health Protection, Tatar State Humanitarian Pedagogical University.

出版信息

Bull Exp Biol Med. 2007 Aug;144(2):171-3. doi: 10.1007/s10517-007-0281-x.

DOI:10.1007/s10517-007-0281-x

PMID:18399272

Abstract

We studied the role of M3 cholinergic receptors in the regulation of cardiac activity in rats during early postnatal ontogeny in vivo. Blockade of M3 cholinergic receptors in 20-week-old animals increased heart rate and decreased blood pressure. In rats aging 8, 6, and 3 weeks, blockade of M3 cholinergic receptors had little effect on R-R interval, but unexpectedly increased it in 1-week-old animals. It can be hypothesized that tonic inhibitory effect of the vagus nerve in adult rats is realized through M3 cholinergic receptors of the heart. The decrease in heart rate during blockade of M3 cholinergic receptors in 1-week-old rats was probably related to specific innervation of the heart in animals of this age.

摘要

我们在体内研究了M3胆碱能受体在大鼠出生后早期个体发育过程中对心脏活动调节的作用。在20周龄动物中阻断M3胆碱能受体会增加心率并降低血压。在8周、6周和3周龄的大鼠中，阻断M3胆碱能受体对R-R间期影响不大，但出乎意料的是，在1周龄动物中却增加了R-R间期。可以推测，成年大鼠迷走神经的紧张性抑制作用是通过心脏的M3胆碱能受体实现的。1周龄大鼠阻断M3胆碱能受体时心率下降可能与该年龄动物心脏的特定神经支配有关。