Wood Nelson, Johnson Roger B
Department of Periodontics and Preventive Sciences, University of Mississippi Medical Center, Mississippi, USA.
Oral Health Prev Dent. 2008;6(1):67-74.
To examine the risks for being overweight (Ow) or obese (Ob) in subjects with elevated Periodontal Screening and Recording (PSRTM) Codes (> or =1) (with smoking as a modifier) in a population of dental school patients located within a region with a high incidence of Ow, Ob, diabetes mellitus (Db), and cardiovascular disease (CVD).
1098 patient files were studied and data were grouped by average PSR Codes, smoking history, and body mass index (BMI). Data were compared by factorial ANOVA, the Mann-Whitney U test, and chi-square analysis using PSRTM Code as an exposure for BMI, Db, or CVD, with smoking as the effect modifier. Data were then analysed by adjusted multivariate logistic regression to determine the risks for being Ow or Ob.
Subjects with an average PSRTM Code > or =1 and a smoking history did not have a significantly increased risk for either Db or CVD. Non-smoking subjects with an average PSR Code =3 had a significantly higher risk for being Ow; those with an average PSR Code of 2-4 had a significantly higher risk for being Ob (p < 0.05). In contrast, only smokers with an average PSR Code =4 had a significant risk for being either Ow or Ob.
Our data suggest that smoking may not directly increase the risk factors for Db or CVD in subjects with an average PSRTM Code > 1 (confirming the 'Smoker's Paradox'), but could be an indirect risk factor for these diseases as a consequence of its effect on body weight.
在一个超重、肥胖、糖尿病(Db)和心血管疾病(CVD)高发地区的牙科学校患者群体中,研究牙周筛查与记录(PSRTM)代码升高(≥1)(以吸烟作为修饰因素)的受试者超重(Ow)或肥胖(Ob)的风险。
研究了1098份患者档案,并根据平均PSR代码、吸烟史和体重指数(BMI)对数据进行分组。以PSRTM代码作为BMI、Db或CVD的暴露因素,吸烟作为效应修饰因素,通过析因方差分析、曼-惠特尼U检验和卡方分析对数据进行比较。然后通过调整后的多变量逻辑回归分析数据,以确定超重或肥胖的风险。
平均PSRTM代码≥1且有吸烟史的受试者患Db或CVD的风险没有显著增加。平均PSR代码=3的非吸烟受试者超重风险显著更高;平均PSR代码为2-4的受试者肥胖风险显著更高(p<0.05)。相比之下,只有平均PSRTM代码=4的吸烟者有超重或肥胖的显著风险。
我们的数据表明,吸烟可能不会直接增加平均PSRTM代码>1的受试者患Db或CVD的风险因素(证实了“吸烟者悖论”),但由于其对体重的影响,可能是这些疾病的间接风险因素。