Nuti A, Maremmani C, Ceravolo R, Pavese N, Bonuccelli U, Muratorio A
Istituto di Clinica Neurologica, Università di Pisa.
Riv Neurol. 1991 Nov-Dec;61(6):225-7.
Neuroleptic drugs represent the current therapy for Huntington's chorea (HC). However neuroleptics can improve involuntary movements, but not functional performance and disease progression. Several clinical and experimental data suggest the existence of functional relationship between corticosteroids and extrapyramidal system. We administered dexamethasone to six choreics, all female. Dexamethasone was given i.m. at dose of 4 mg/die for 20 days and 8 mg/die for 20 days more. Dexamethasone at both the doses used, determined significant improvement (p less than 0.05) of dyskinesia, evaluated by AIMS, and manual dexterity, evaluated by Tapping test. Although at present it is not clear which mechanism are responsible for this of dexamethasone favourable effect, it might open new perspectives in HC therapy.
抗精神病药物是目前治疗亨廷顿舞蹈症（HC）的方法。然而，抗精神病药物可以改善不自主运动，但不能改善功能表现和疾病进展。一些临床和实验数据表明，皮质类固醇与锥体外系之间存在功能关系。我们对6名患有舞蹈症的女性患者给予了地塞米松。地塞米松通过肌肉注射给药，剂量为4毫克/天，持续20天，之后剂量增加到8毫克/天，再持续20天。使用的这两种剂量的地塞米松，通过异常不自主运动量表（AIMS）评估，均使运动障碍得到了显著改善（p<0.05），通过敲击试验评估，手部灵活性也得到了显著改善。虽然目前尚不清楚地塞米松产生这种有利作用的机制是什么，但它可能为HC治疗开辟新的前景。
