• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24](6-) polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate.

作者信息

Cartuyvels Els, Absillis Gregory, Parac-Vogt Tatjana N

机构信息

Katholieke Universiteit Leuven, Department of Chemistry, Celestijnenlaan 200F, B-3001 Leuven, Belgium.

出版信息

Chem Commun (Camb). 2008 Jan 7(1):85-7. doi: 10.1039/b714860g.

DOI:10.1039/b714860g
PMID:18399409
Abstract

The first example of a phosphodiester bond cleavage promoted by a highly negatively charged polyoxometalate cluster has been discovered: the hydrolysis of the phosphodiester bond in a DNA model substrate bis(p-nitrophenyl)phosphate (BNPP) is promoted by the heptamolybdate anion Mo7O24 with rates which represent an acceleration of nearly four orders of magnitude compared to the uncatalyzed cleavage.

摘要

相似文献

1
Questioning the paradigm of metal complex promoted phosphodiester hydrolysis: [Mo7O24](6-) polyoxometalate cluster as an unlikely catalyst for the hydrolysis of a DNA model substrate.
Chem Commun (Camb). 2008 Jan 7(1):85-7. doi: 10.1039/b714860g.
2
Hydrolysis of DNA model substrates catalyzed by metal-substituted Wells-Dawson polyoxometalates.金属取代的 Wells-Dawson 多金属氧酸盐催化 DNA 模型底物的水解。
Dalton Trans. 2012 Sep 7;41(33):10028-34. doi: 10.1039/c2dt30588g. Epub 2012 May 18.
3
Hydrolytic cleavage of an RNA-model phosphodiester catalyzed by a highly negatively charged polyoxomolybdate [Mo7O24]6- cluster.由高负电荷的多氧钼酸盐[Mo7O24]6-簇催化的RNA模型磷酸二酯的水解裂解。
J Am Chem Soc. 2008 Dec 24;130(51):17400-8. doi: 10.1021/ja804823g.
4
Hydrolysis of the RNA model substrate catalyzed by a binuclear Zr(IV)-substituted Keggin polyoxometalate.由双核锆（IV）取代的Keggin型多金属氧酸盐催化的RNA模型底物的水解反应。
Dalton Trans. 2015 Sep 21;44(35):15690-6. doi: 10.1039/c5dt02077h.
5
Multinuclear diffusion NMR spectroscopy and DFT modeling: a powerful combination for unraveling the mechanism of phosphoester bond hydrolysis catalyzed by metal-substituted polyoxometalates.多核扩散核磁共振光谱与密度泛函理论建模：揭示金属取代多金属氧酸盐催化磷酸酯键水解机制的有力组合。
Chemistry. 2015 Mar 9;21(11):4428-39. doi: 10.1002/chem.201405810. Epub 2015 Feb 4.
6
Triisopropyltriazacyclononane copper(II): an efficient phosphodiester hydrolysis catalyst and DNA cleavage agent.三异丙基三氮杂环壬烷铜（II）：一种高效的磷酸二酯水解催化剂和DNA切割剂。
Inorg Chem. 2002 Feb 25;41(4):669-77. doi: 10.1021/ic0107025.
7
Metal-organic frameworks with phosphotungstate incorporated for hydrolytic cleavage of a DNA-model phosphodiester.含磷钨酸盐的金属有机骨架用于 DNA 模型磷酸二酯键的水解断裂。
Inorg Chem. 2012 May 7;51(9):5118-27. doi: 10.1021/ic202685e. Epub 2012 Apr 9.
8
Polyoxomolybdate promoted hydrolysis of a DNA-model phosphoester studied by NMR and EXAFS spectroscopy.多酸促进 DNA 模型磷酸酯的水解研究的 NMR 和 EXAFS 光谱。
Inorg Chem. 2011 Nov 21;50(22):11552-60. doi: 10.1021/ic201498u. Epub 2011 Oct 26.
9
A calix[4]arene with acylguanidine units as an efficient catalyst for phosphodiester bond cleavage in RNA and DNA model compounds.酰基胍基杯[4]芳烃作为一种高效催化剂，用于断裂 RNA 和 DNA 模型化合物中的磷酸二酯键。
Org Biomol Chem. 2019 Aug 28;17(32):7482-7492. doi: 10.1039/c9ob01141b. Epub 2019 Jul 31.
10
Mechanistic insights for β-cyclodextrin catalyzed phosphodiester hydrolysis.β-环糊精催化磷酸二酯水解的机理见解。
J Mol Model. 2014 Apr;20(4):2198. doi: 10.1007/s00894-014-2198-4. Epub 2014 Mar 22.

引用本文的文献

1
New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes.关于菲咯啉类配体和金属配合物与多酸化合物与双链 DNA 和 G-四链体相互作用的新见解。
Molecules. 2021 Aug 5;26(16):4737. doi: 10.3390/molecules26164737.
2
Amide Bond Activation of Biological Molecules.生物分子的酰胺键活化。
Molecules. 2018 Oct 12;23(10):2615. doi: 10.3390/molecules23102615.
3
Selectivity and Reactivity of Zr and Ce Substituted Keggin Type Polyoxometalates Toward Cytochrome c in Surfactant Solutions.
表面活性剂溶液中锆和铈取代的Keggin型多金属氧酸盐对细胞色素c的选择性和反应性
Front Chem. 2018 Aug 28;6:372. doi: 10.3389/fchem.2018.00372. eCollection 2018.
4
Highly Selective and Tunable Protein Hydrolysis by a Polyoxometalate Complex in Surfactant Solutions: A Step toward the Development of Artificial Metalloproteases for Membrane Proteins.多金属氧酸盐配合物在表面活性剂溶液中实现的高选择性和可调性蛋白质水解：迈向膜蛋白人工金属蛋白酶开发的一步。
ACS Omega. 2017 May 31;2(5):2026-2033. doi: 10.1021/acsomega.7b00168. Epub 2017 May 11.
5
Polyoxometalates as Potential Next-Generation Metallodrugs in the Combat Against Cancer.多金属氧酸盐作为新一代金属药物在抗癌中的应用潜力。
Angew Chem Int Ed Engl. 2019 Mar 4;58(10):2980-2999. doi: 10.1002/anie.201803868. Epub 2018 Oct 12.