Pisani Michela, Fino Vincenzo, Bruni Paolo, Cola Emanuela Di, Francescangeli Oriano
J Phys Chem B. 2008 May 1;112(17):5276-8. doi: 10.1021/jp802211r. Epub 2008 Apr 10.
Metal cations (Mn(2+) or Ca(2+)) in aqueous dispersions of mixtures of dioleoylphosphatidylethanolamine (DOPE) and poly(ethylene glycol)-functionalized DOPE (DOPE-PEG(350)) induce, above a certain amount of the PEG lipid component, a phase transition from the inverted hexagonal phase H(II) to the bicontinuous inverted cubic phase Q(224) with space group Pn3m. The process is driven by the decrease of free elastic energy due to the Gaussian curvature of the cubic phase. The structural characterization of the phase behavior over the whole explored range of DOPE-PEG/DOPE weight ratio (3-25%) is reported, focusing on the role of the metal cation in the formation of the 3D cubic lattice. This result may represent a significant progress toward a design-based approach to drug delivery.
在二油酰磷脂酰乙醇胺（DOPE）与聚乙二醇功能化的DOPE（DOPE-PEG(350)）混合物的水分散体中，金属阳离子（Mn(2+)或Ca(2+)）在一定量的PEG脂质组分以上时，会引发从反相六角相H(II)到具有空间群Pn3m的双连续反相立方相Q(224)的相变。该过程由立方相的高斯曲率导致的自由弹性能降低所驱动。报道了在整个探索的DOPE-PEG/DOPE重量比范围（3-25%）内相行为的结构表征，重点关注金属阳离子在三维立方晶格形成中的作用。这一结果可能代表了基于设计的药物递送方法取得的重大进展。
