Falanga Vincent, Chartier Molly, Butmarc Janet, Tibbetts Lance
Department of Dermatology and Skin Surgery, Roger Williams Medical Center, Providence, RI 02908, USA.
J Cutan Pathol. 2008 May;35(5):473-6. doi: 10.1111/j.1600-0560.2007.00829.x.
We report on a case of the collision of a desmoplastic-neurotropic melanoma and a squamous cell carcinoma on the lip. A 46-year-old male developed a multifocal infiltrative squamous cell carcinoma of the lower lip, which also showed sparse melanocyte atypia within the epidermis and an extensive spindle cell proliferation within the dermis, subcutaneous tissues and nerves. An immunohistochemical panel showed that the spindle cells were melanocytes, not derived from the squamous cell carcinoma. Double labeling with AE1/AE3 and S100 showed striking localized proximity of the spindle-cell melanocytic and keratinocyte components in some areas of this tumor. To our knowledge, this is the first report of the collision of a squamous cell carcinoma and desmoplastic-neurotropic melanoma.
我们报告一例唇部促纤维增生性嗜神经性黑色素瘤与鳞状细胞癌碰撞的病例。一名46岁男性下唇出现多灶性浸润性鳞状细胞癌，其表皮内也可见散在的黑素细胞异型性，真皮、皮下组织及神经内有广泛的梭形细胞增殖。免疫组织化学检查显示梭形细胞为黑素细胞，并非来源于鳞状细胞癌。AE1/AE3和S100双重标记显示，在该肿瘤的某些区域，梭形细胞黑素细胞成分与角质形成细胞成分显著局部相邻。据我们所知，这是鳞状细胞癌与促纤维增生性嗜神经性黑色素瘤碰撞的首例报告。
