Tseke Paraskevi, Grapsa Eirini, Stamatelopoulos Kimon, Samouilidou Elizabeth, Rammos George, Papamichael Christos, Zakopoulos Nikolaos
Renal Unit, General Hospital Alexandra, University of Athens, Athens, Greece.
Blood Purif. 2008;26(3):261-6. doi: 10.1159/000124850. Epub 2008 Apr 10.
Serum total sialic acid (S-TSA) is associated with atherosclerotic process in general population. The aim of our study was to evaluate possible correlations of S-TSA with markers of inflammation and atherosclerosis in hemodialysis (HD) patients.
We involved 53 asymptomatic, nondiabetic HD patients and 28 healthy controls. Atherosclerosis was evaluated by carotid ultrasonography, estimating intima media wall thickness and wall to lumen ratio bilaterally. To confirm our findings, we performed a 32-month cohort study, during which cardiovascular (CV) events were analyzed in relation to S-TSA concentration.
HD patients had higher S-TSA compared to controls (adjusted OR: 1.04, p = 0.026). In HD patients, S-TSA independently correlated with hs-CRP (p < 0.0001), lipoprotein(a) (p = 0.02), intima media wall thickness (p = 0.023) and wall to lumen ratio (p = 0.028). Increased S-TSA concentration was associated with more CV events (p = 0.03).
Serum TSA seems to correlate with inflammation, accelerated atherosclerosis and CV events in nondiabetic HD patients, but more studies need to confirm our findings.
血清总唾液酸（S - TSA）与普通人群的动脉粥样硬化进程相关。我们研究的目的是评估血液透析（HD）患者中S - TSA与炎症及动脉粥样硬化标志物之间可能存在的相关性。
我们纳入了53例无症状、非糖尿病的HD患者和28例健康对照者。通过双侧颈动脉超声检查评估动脉粥样硬化情况，测量内膜中层厚度及壁腔比。为证实我们的研究结果，我们进行了一项为期32个月的队列研究，在此期间分析心血管（CV）事件与S - TSA浓度的关系。
HD患者的S - TSA水平高于对照组（校正比值比：1.04，p = 0.026）。在HD患者中，S - TSA与超敏C反应蛋白（hs - CRP）（p < 0.0001）、脂蛋白（a）（p = 0.02）、内膜中层厚度（p = 0.023）及壁腔比（p = 0.028）独立相关。S - TSA浓度升高与更多的CV事件相关（p = 0.03）。
血清TSA似乎与非糖尿病HD患者的炎症、加速的动脉粥样硬化及CV事件相关，但需要更多研究来证实我们的发现。
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