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[各种病因引起的黄斑水肿]

[Macular edema from various etiologies].

作者信息

Cornut P-L, Français-Maury C, Mauget-Faÿsse M

机构信息

Service d'Ophtalmologie, Hôpital Edouard Herriot, Lyon.

出版信息

J Fr Ophtalmol. 2008 Feb;31(2):225-33. doi: 10.1016/s0181-5512(08)70361-9.

Abstract

Macular edema typically occurs as the final ocular manifestation of many intraocular or systemic diseases with fluid collection within the macular layers due to the breakdown of the blood-retinal barrier. This could be chemically mediated by VEGF, because increased VEGF has been shown to increase blood-retinal barrier permeability, or mechanically induced by vitreomacular traction causing hemodynamic or retinal pigment epithelium pump disturbances. This article reviews the different clinical entities of macular edema, focusing on their physiopathological concepts and on the current therapeutic strategies for their management.

摘要

黄斑水肿通常是许多眼内或全身性疾病的最终眼部表现,由于血视网膜屏障破坏,黄斑层内会有液体聚集。这可能由血管内皮生长因子(VEGF)化学介导,因为已表明VEGF增加会导致血视网膜屏障通透性增加,或者由玻璃体黄斑牵引机械诱导,引起血流动力学或视网膜色素上皮泵功能紊乱。本文综述了黄斑水肿的不同临床类型,重点关注其生理病理概念以及当前的治疗策略。

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