粒细胞-巨噬细胞集落刺激因子与中性粒细胞：作用机制 - Suppr

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超能文献

Granulocyte-macrophage colony-stimulating factor and the neutrophil: mechanisms of action.

作者信息

Gomez-Cambronero J, Sha'afi R I

机构信息

Department of Physiology, University of Connecticut Health Center, Farmington 06030.

出版信息

Adv Exp Med Biol. 1991;314:35-71. doi: 10.1007/978-1-4684-6024-7_3.

DOI:10.1007/978-1-4684-6024-7_3

PMID:1840169

Abstract

摘要

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Granulocyte-macrophage colony-stimulating factor and the neutrophil: mechanisms of action.粒细胞-巨噬细胞集落刺激因子与中性粒细胞：作用机制

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes phosphorylation and an increase in the activity of cytosolic phospholipase A2 in human neutrophils.粒细胞巨噬细胞集落刺激因子（GM-CSF）可促进人中性粒细胞中胞质磷脂酶A2的磷酸化并提高其活性。

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Up-regulation of the amount of Gi alpha 2 associated with the plasma membrane in human neutrophils stimulated by granulocyte-macrophage colony-stimulating factor.粒细胞-巨噬细胞集落刺激因子刺激的人中性粒细胞中，与质膜相关的Giα2量上调。

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Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils.粒细胞巨噬细胞集落刺激因子通过酪氨酸磷酸化对人中性粒细胞微管相关蛋白（MAP）激酶活性进行直接刺激。

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