Kalinichenko S G, Matveeva N Yu
Department of Histology, Vladivostok State Medical University, Vladivostok.
Neurosci Behav Physiol. 2008 May;38(4):333-44. doi: 10.1007/s11055-008-0046-7.
Results from our own studies and published data are used to provide a critical analysis of current views of the role of apoptosis in regulating the quantitative and qualitative constancy of cells in the developing brain. Detailed descriptions of the morphological features and mechanisms of the different phases of apoptotic neuron death are given. Apoptosis affects the ordering of connections in neural networks and is involved in the pathogenesis of neurodegenerative diseases--epilepsy, schizophrenia, and Alzheimer's disease. The question of the interaction of the NO-ergic mechanism and the cell in executing apoptosis is discussed. The data allow NO to be regarded as a cytotoxic factor which induces apoptosis. The ultrastructural features of post-mitotic immature neurons suggests the operation of the apoptotic and necrosis-like (NO-dependent) pathways of natural cell death during the process of differentiation.
我们自己的研究结果和已发表的数据被用于对当前关于凋亡在调节发育中大脑细胞数量和质量稳定性方面作用的观点进行批判性分析。文中给出了凋亡神经元死亡不同阶段的形态特征和机制的详细描述。凋亡影响神经网络中连接的有序性，并参与神经退行性疾病——癫痫、精神分裂症和阿尔茨海默病的发病机制。文中讨论了一氧化氮能机制与细胞在执行凋亡过程中的相互作用问题。这些数据使一氧化氮被视为诱导凋亡的细胞毒性因子。有丝分裂后未成熟神经元的超微结构特征表明，在分化过程中存在自然细胞死亡的凋亡和类坏死（一氧化氮依赖性）途径。
