Ebrahimi Rasoul, Faramarzi Ali, Salarvandian Shakiba, Zarei Reyhaneh, Heidari Moghadaseh, Salehian Fatemeh, Esmaeilpour Khadijeh
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mol Neurobiol. 2025 May 29. doi: 10.1007/s12035-025-05095-x.
Melatonin supplementation shows potential therapeutic effects in Alzheimer's disease (AD) by targeting impaired neurogenesis. Neurogenesis, the formation of new neurons after development, involves proliferation, migration, differentiation, and survival of neurons. Impaired neurogenesis is associated with AD, specifically in the subventricular zone (SVZ) and subgranular zone (SGZ), leading to hippocampal degeneration and memory impairment. Melatonin positively effects AD by regulating amyloid beta (Aβ)-induced neuroinflammation, reducing tau hyperphosphorylation, and enhancing adult neurogenesis through various signaling pathways. In addition, it has anti-apoptotic, antioxidative, and anti-inflammatory properties, suggesting its potential as a treatment option for AD progression. Furthermore, melatonin and sleep are closely linked, and an increase in sleep duration positively affects Aβ deposition. This review aims to examine the impact of AD pathologies on neurogenesis and explore the mechanisms by which melatonin may alleviate these pathologies, potentially promoting neurogenesis.
补充褪黑素通过针对受损的神经发生显示出在阿尔茨海默病（AD）中的潜在治疗作用。神经发生是指发育后新神经元的形成，涉及神经元的增殖、迁移、分化和存活。神经发生受损与AD有关，特别是在脑室下区（SVZ）和颗粒下区（SGZ），导致海马体退化和记忆障碍。褪黑素通过调节β-淀粉样蛋白（Aβ）诱导的神经炎症、减少tau蛋白过度磷酸化以及通过各种信号通路增强成体神经发生，对AD产生积极影响。此外，它具有抗凋亡、抗氧化和抗炎特性，表明其作为AD进展治疗选择的潜力。此外，褪黑素与睡眠密切相关，睡眠时间的增加对Aβ沉积有积极影响。本综述旨在研究AD病理对神经发生的影响，并探索褪黑素可能减轻这些病理、潜在促进神经发生的机制。
