Edwards Y H, Fox M F, Povey S, Hinks L J, Thompson R J, Day I N
M.R.C. Human Biochemical Genetics Unit, Galton Laboratory, London.
Ann Hum Genet. 1991 Oct;55(4):273-8. doi: 10.1111/j.1469-1809.1991.tb00853.x.
Ubiquitin carboxy terminal hydrolase 1, UCHL1, is a neurone-specific protein involved in the ubiquitin-mediated proteolytic pathway. The gene for human UCHL1 has been mapped to chromosome 4 using the polymerase chain reaction to amplify specifically the human UCHL1 sequences in rodent/human somatic cell hybrid DNA. A regional assignment of this locus to 4p14 has been made by in situ hybridization to metaphase chromosomes using both tritium and fluorescently labelled probes.
泛素羧基末端水解酶1（UCHL1）是一种参与泛素介导的蛋白水解途径的神经元特异性蛋白。利用聚合酶链反应特异性扩增啮齿动物/人类体细胞杂交DNA中的人类UCHL1序列，已将人类UCHL1基因定位于4号染色体。通过使用氚和荧光标记探针与中期染色体进行原位杂交，已将该基因座定位到4p14区域。
