铑催化2-炔基芳基异氰酸酯与双(频哪醇)二硼的硼氢化环化反应。
Rhodium-catalyzed borylative cyclization of 2-alkynylaryl isocyanates with bis(pinacolato)diboron.
作者信息
Miura Tomoya, Takahashi Yusuke, Murakami Masahiro
机构信息
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Japan.
出版信息
Org Lett. 2008 May 1;10(9):1743-5. doi: 10.1021/ol800380t. Epub 2008 Apr 11.
PMID:18402456
Abstract
2-alkynylaryl isocyanates reacted with bis(pinacolato)diboron in the presence of a cationic rhodium(I) catalyst to produce borylated 3-alkylideneoxindoles stereoselectively. The carbon-boron linkage formed was further transformed via reactions such as a cross-coupling and a halogenation reaction.
摘要
2-炔基芳基异氰酸酯在阳离子铑（I）催化剂存在下与双（频哪醇）二硼反应，立体选择性地生成硼化的3-亚烷基氧化吲哚。形成的碳-硼键通过交叉偶联和卤化反应等进一步转化。
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