Agostini Aubert, Provansal Magali, Collette Emmanuelle, Capelle Mariane, Estrade Jean Philippe, Cravello Ludovic, Gamerre Marc
Department of Obstetrics and Gynecology, La Conception University Hospital, 147 Boulevard Baille, Marseille Cedex 05, France.
Contraception. 2008 May;77(5):382-5. doi: 10.1016/j.contraception.2008.01.009. Epub 2008 Mar 21.
The study was conducted to compare the effectiveness of ropivacaine and lidocaine as paracervical analgesia for elective abortion by vacuum aspiration.
This single-center double-blinded randomized study tested two different agents for paracervical analgesia in elective abortions: lidocaine (n=57) or ropivacaine (n=57). We assessed intra- and postoperative pain according to both a visual analogical scale rated from 0 to 10 and postoperative analgesic requirements.
Mean intraoperative pain was significantly lower in the ropivacaine group (5.23+/-2.72 vs. 4.18+/-2.77, p=.048.). There was no significant difference in mean assessed pain at the end of the intervention or at 2 or 4 h afterward. The rate of subjects requiring additional postoperative analgesia did not differ significantly between the lidocaine and ropivacaine groups [8/59 (13.5%) vs. 6/59 (10.1%), p=.33].
Intraoperative pain appears to be less with ropivacaine than with lidocaine. Nonetheless, the clinical difference was slight, as was therefore the benefit of using ropivacaine for paracervical block in elective abortions.
本研究旨在比较罗哌卡因和利多卡因作为宫颈旁神经阻滞用于真空吸引术选择性流产镇痛的有效性。
这项单中心双盲随机研究测试了两种不同药物用于选择性流产的宫颈旁神经阻滞:利多卡因(n = 57)或罗哌卡因(n = 57)。我们根据0至10的视觉模拟评分量表以及术后镇痛需求评估术中及术后疼痛。
罗哌卡因组术中平均疼痛明显更低(5.23±2.72对4.18±2.77,p = 0.048)。干预结束时、干预后2小时或4小时评估的平均疼痛无显著差异。利多卡因组和罗哌卡因组术后需要额外镇痛的受试者比例无显著差异[8/59(13.5%)对6/59(10.1%),p = 0.33]。
罗哌卡因术中疼痛似乎比利多卡因少。尽管如此,临床差异很小,因此在选择性流产中使用罗哌卡因进行宫颈旁阻滞的益处也很小。