Houle Timothy T, Stump David A
Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Semin Cardiothorac Vasc Anesth. 2008 Mar;12(1):5-6. doi: 10.1177/1089253208316440. Epub 2008 Apr 9.
Unfortunately, the data were statistically nonsignificant due to insufficient power and poor experimental design. Conversely, many large clinical trials obtain a high level of statistical significance with miniscule differences between groups, which are completely clinically irrelevant. However, with proper marketing, billions can be made from results of dubious clinical importance. In this article, the differences between statistical and clinical significance are briefly discussed.
不幸的是，由于检验效能不足和实验设计不佳，数据在统计学上无显著意义。相反，许多大型临床试验显示出高度的统计学显著性，但组间差异极小，而这些差异在临床上完全无关紧要。然而，通过适当的营销手段，从临床重要性存疑的结果中也能赚取数十亿美元。本文将简要讨论统计学显著性和临床显著性之间的差异。
