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原位心脏移植中标准术式与双腔静脉术式的比较:10年随访

Comparison of standard and bicaval approach in orthotopic heart transplantation: 10-year follow-up.

作者信息

Grande Antonino M, Gaeta Roberto, Campana Carlo, Klersy Catherine, Riva Laura, D'Armini Andrea M, Viganò Mario

机构信息

Divisione Cardiochirurgia, Istituto di Chirurgia Generale e dei Trapianti d'Organo, Fondazione IRCCS Policlinico S. Matteo, Università degli Studi di Pavia, Pavia, Italy.

出版信息

J Cardiovasc Med (Hagerstown). 2008 May;9(5):493-7. doi: 10.2459/JCM.0b013e3282f19365.

Abstract

BACKGROUND

The present study compared 86 patients who underwent orthotopic heart transplantation by bicaval and standard techniques.

METHODS

Patients already followed in the first year after heart transplantation were studied at 10 years of follow-up, this time evaluating the prevalence of arrhythmias, conduction disturbances and mitral or tricuspid regurgitation.

RESULTS

The following arrhythmias were observed: atrial fibrillation (one patient from the standard group), ventricular premature beats and ventricular fibrillation (each in one patient from the bicaval group). Conduction disturbances were found in 25 patients in the standard group (48.1%) and in 19 patients in the bicaval group (55.9%, P = 0.515). Twenty patients had a mono- or bifascicular block in the standard group (38.5%) versus 19 patients in the bicaval group (55.9%); furthermore, five patients in the standard group (9.6%) and none in the bicaval group had a permanent pacemaker (Fisher's exact test: P = 0.074). Mitral regurgitation was present in 13 (26.5%) and five (16.1%) patients, respectively, in the standard and bicaval groups (Fisher's exact test: P = 0.411): it was grade 1 in 12 and five patients and grade 2 in one and zero patients, respectively. Tricuspidal regurgitation was observed in 26 (53.1%) and 13 (41.9%) patients, respectively, in the standard and bicaval groups (Fisher's exact test: P = 0.366): it was grade 1 in 23 and 13 patients and grade 2 in three and zero patients, respectively. Cumulative survival was 75% at 10 years from transplant in this relatively old population of patients (mean age = 58 years).

CONCLUSION

In conclusion, our data do not support any definite mandate for either of the surgical techniques.

摘要

背景

本研究比较了86例接受双腔和标准技术原位心脏移植的患者。

方法

对心脏移植后第一年已接受随访的患者进行10年随访研究,此次评估心律失常、传导障碍以及二尖瓣或三尖瓣反流的发生率。

结果

观察到以下心律失常:房颤(标准组1例患者)、室性早搏和室颤(双腔组各1例患者)。标准组25例患者(48.1%)和双腔组19例患者(55.9%)存在传导障碍(P = 0.515)。标准组20例患者(38.5%)存在单束支或双束支阻滞,双腔组为19例患者(55.9%);此外,标准组5例患者(9.6%)植入了永久起搏器,双腔组无患者植入(Fisher精确检验:P = 0.074)。标准组和双腔组二尖瓣反流分别存在于13例(26.5%)和5例(16.1%)患者中(Fisher精确检验:P = 0.411):标准组12例和双腔组5例患者为1级反流,标准组1例和双腔组0例患者为2级反流。标准组和双腔组三尖瓣反流分别见于26例(53.1%)和13例(41.9%)患者(Fisher精确检验:P = 0.366):23例和13例患者为1级反流,3例和0例患者为2级反流。在这个年龄相对较大的患者群体(平均年龄 = 58岁)中,移植后10年的累积生存率为75%。

结论

总之,我们的数据不支持对任何一种手术技术有明确的偏好。

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