Olmarker Kjell
Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, Göteborg University, Gothenburg, Sweden.
Spine (Phila Pa 1976). 2008 Apr 15;33(8):850-5. doi: 10.1097/BRS.0b013e31816b46ca.
Changes in spontaneous behavior was studied in rats after a controlled puncture of a lumbar intervertebral disc.
To study if puncture of a lumbar disc would induce recordable changes in spontaneous pain behavior.
Anular tears are common and may be found both in patients with low back pain and in asymptomatic patients. It has been suggested that anular injury may relate to low back pain either by stimulation of local sensory receptors in the posterior part of the anulus fibrosus or by ingrowth of newly formed nerve fibers into the deeper parts of the disc. The objective of the study was to analyze if a controlled puncture of a lumbar intervertebral disc might induce recordable changes in spontaneous behavior of rats.
After anesthesia, the L4-L5 disc was punctured in 10 rats. Ten other rats received sham surgery. Spontaneous behavior was assessed at days 1, 3, 7, 14, and 21 after surgery.
Statistically significant differences in behavior were seen at all days analyzed. Most consistent were increases in "grooming" and in "wet-dog shakes."
Puncture of a lumbar intervertebral disc in the rat produces changes in spontaneous behavior mainly seen as increased "grooming" and "wet-dog shakes," 2 behaviors that have been suggested to indicate stress and pain.
在对大鼠进行可控的腰椎间盘穿刺后，研究其自发行为的变化。
研究腰椎间盘穿刺是否会在自发疼痛行为上引起可记录的变化。
纤维环撕裂很常见，在腰痛患者和无症状患者中均可能出现。有人提出，纤维环损伤可能通过刺激纤维环后部的局部感觉受体或通过新生神经纤维长入椎间盘深部而与腰痛相关。本研究的目的是分析可控的腰椎间盘穿刺是否会在大鼠的自发行为上引起可记录的变化。
对10只大鼠在麻醉后进行L4-L5椎间盘穿刺。另外10只大鼠接受假手术。在术后第1、3、7、14和21天评估自发行为。
在所有分析的天数中，行为上均出现了统计学上的显著差异。最一致的变化是“梳理毛发”和“像湿狗一样抖动”行为增加。
大鼠腰椎间盘穿刺会引起自发行为的变化，主要表现为“梳理毛发”和“像湿狗一样抖动”行为增加，这两种行为被认为表明存在应激和疼痛。
