抑郁症、皮质醇与躯体形式解离症状。
Depression, cortisol and somatoform dissociative symptoms.
作者信息
Bob Petr, Freybergh P F, Jasova Denisa, Susta Marek, Pavlat Josef, Zima Tomas, Benakova Hana, Bizik Gustav, Svetlak Miroslav, Vevera Jan, Miklosko Jozef, Hajek Karel, Raboch Jiri
机构信息
Centre for Neuropsychiatric Research of Traumatic Stress and Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
出版信息
Neuro Endocrinol Lett. 2008 Apr;29(2):235-9.
OBJECTIVE
According to recent findings neuroendocrine response related to dissociative symptoms is related to dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis but HPA axis functioning as related to dissociation is only partially understood.
METHOD
With the aim to test the relationship between basal serum cortisol and dissociative symptoms measured as somatoform and psychic dissociation we performed clinical testing and biochemical analysis in 30 inpatients with diagnosis of unipolar depression (mean age 41.46, SD=13.68).
RESULTS
The results show that cortisol as an index of HPA axis functioning manifests significant relationship to somatoform dissociative symptoms (r=-0.40; p=0.014).
CONCLUSIONS
The result indicates relationship between HPA-axis reactivity and somatoform dissociative symptoms in unipolar depressive patients and suggests that somatoform dissociation presents a defense mechanism related to a passive coping response.
目的
根据最近的研究结果，与分离症状相关的神经内分泌反应与下丘脑-垂体-肾上腺（HPA）轴功能失调有关，但HPA轴功能与分离的关系仅得到部分理解。
方法
为了测试基础血清皮质醇与以躯体形式解离和精神性解离衡量的分离症状之间的关系，我们对30名诊断为单相抑郁症的住院患者（平均年龄41.46，标准差=13.68）进行了临床测试和生化分析。
结果
结果显示，作为HPA轴功能指标的皮质醇与躯体形式分离症状存在显著关系（r=-0.40；p=0.014）。
结论
该结果表明单相抑郁患者的HPA轴反应性与躯体形式分离症状之间存在关联，并表明躯体形式解离呈现出一种与被动应对反应相关的防御机制。
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