那条拒绝消亡的性染色体。
The sex chromosome that refused to die.
作者信息
Malone John H, Oliver Brian
机构信息
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
出版信息
Bioessays. 2008 May;30(5):409-11. doi: 10.1002/bies.20752.
Abstract
Chromosomes that harbor dominant sex determination loci are predicted to erode over time--losing genes, accumulating transposable elements, degenerating into a functional wasteland and ultimately becoming extinct. The Drosophila melanogaster Y chromosome is fairly far along this path to oblivion. The few genes on largely heterochromatic Y chromosome are required for spermatocyte-specific functions, but have no role in other tissues. Surprisingly, a recent paper shows that divergent Y chromosomes can substantially influence gene expression throughout the D. melanogaster genome.1 These results show that variation on Y has an important influence on the deployment of the genome.
摘要
携带显性性别决定基因座的染色体预计会随着时间的推移而退化——失去基因、积累转座元件、退化为功能荒芜之地并最终灭绝。黑腹果蝇的Y染色体在这条走向遗忘的道路上已经走得相当远了。在很大程度上是异染色质的Y染色体上的少数基因是精母细胞特异性功能所必需的，但在其他组织中没有作用。令人惊讶的是，最近的一篇论文表明，不同的Y染色体可以显著影响整个黑腹果蝇基因组的基因表达。这些结果表明，Y染色体的变异对基因组的部署有重要影响。
相似文献
1
The sex chromosome that refused to die.那条拒绝消亡的性染色体。
Bioessays. 2008 May;30(5):409-11. doi: 10.1002/bies.20752.
2
Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences.多态性Y染色体携带具有多种功能后果的隐秘变异。
Science. 2008 Jan 4;319(5859):91-3. doi: 10.1126/science.1148861.
3
Heterochromatin-Enriched Assemblies Reveal the Sequence and Organization of the Y Chromosome.富含异染色质的组装揭示了 Y 染色体的序列和结构。
Genetics. 2019 Jan;211(1):333-348. doi: 10.1534/genetics.118.301765. Epub 2018 Nov 12.
4
A BamHI repeat element is predominantly associated with the degenerating neo-Y chromosome of Drosophila miranda but absent in the Drosophila melanogaster genome.一个BamHI重复元件主要与米兰达果蝇退化的新Y染色体相关，但在黑腹果蝇基因组中不存在。
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1340-4. doi: 10.1073/pnas.89.4.1340.
5
Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin.元分析显示，在果蝇中，由 Y 染色体调控的基因优先定位于抑制性染色质。
Genome Biol Evol. 2013;5(1):255-66. doi: 10.1093/gbe/evt005.
6
Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome.有毒 Y 染色体：年轻 Y 染色体的雄性果蝇中重复表达增加和与年龄相关的异染色质丢失。
PLoS Genet. 2021 Apr 22;17(4):e1009438. doi: 10.1371/journal.pgen.1009438. eCollection 2021 Apr.
7
Birth of a new gene on the Y chromosome of Drosophila melanogaster.黑腹果蝇Y染色体上新基因的诞生。
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12450-5. doi: 10.1073/pnas.1516543112. Epub 2015 Sep 18.
8
Surprising differences in the variability of Y chromosomes in African and cosmopolitan populations of Drosophila melanogaster.在非洲和世界性黑腹果蝇群体中 Y 染色体变异性的惊人差异。
Genetics. 2013 Jan;193(1):201-14. doi: 10.1534/genetics.112.146167. Epub 2012 Oct 19.
9
Accumulation of transposable elements in the heterochromatin and on the Y chromosome of Drosophila simulans and Drosophila melanogaster.转座元件在拟暗果蝇和黑腹果蝇的异染色质及Y染色体上的积累。
J Mol Evol. 1998 Jun;46(6):661-8. doi: 10.1007/pl00006346.
10
The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting.黑腹果蝇的Y染色体表现出全染色体范围的印记。
Genetics. 2002 Nov;162(3):1245-58. doi: 10.1093/genetics/162.3.1245.
引用本文的文献
1
Do Ty3/Gypsy Transposable Elements Play Preferential Roles in Sex Chromosome Differentiation?Ty3/Gypsy转座元件在性染色体分化中是否发挥着优先作用？
Life (Basel). 2022 Apr 1;12(4):522. doi: 10.3390/life12040522.
2
Y Chromosome Genes Affect Male Sensitivity to Microbial Infections.Y染色体基因影响男性对微生物感染的易感性。
Insects. 2021 Jan 5;12(1):30. doi: 10.3390/insects12010030.
3
Evolutionary interaction between W/Y chromosome and transposable elements.W/Y染色体与转座元件之间的进化相互作用。
Genetica. 2016 Jun;144(3):267-78. doi: 10.1007/s10709-016-9895-0. Epub 2016 Mar 21.
4
How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression.Y染色体如何调节全基因组表观遗传状态：基因组折叠、染色质汇聚和基因表达。
J Genomics. 2014 May 1;2:94-103. doi: 10.7150/jgen.8043. eCollection 2014.
5
Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict.多态性 Y 染色体的表观遗传效应调节染色质成分、免疫反应和性冲突。
Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15826-31. doi: 10.1073/pnas.1010383107. Epub 2010 Aug 23.
6
Sex differences in the adolescent brain.青少年大脑的性别差异。
Brain Cogn. 2010 Feb;72(1):46-55. doi: 10.1016/j.bandc.2009.10.008. Epub 2009 Nov 13.
本文引用的文献
1
Genomic degradation of a young Y chromosome in Drosophila miranda.米兰达果蝇中年轻Y染色体的基因组退化。
Genome Biol. 2008;9(2):R30. doi: 10.1186/gb-2008-9-2-r30. Epub 2008 Feb 12.
2
Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences.多态性Y染色体携带具有多种功能后果的隐秘变异。
Science. 2008 Jan 4;319(5859):91-3. doi: 10.1126/science.1148861.
3
FlyBase: integration and improvements to query tools.果蝇数据库：查询工具的整合与改进
Nucleic Acids Res. 2008 Jan;36(Database issue):D588-93. doi: 10.1093/nar/gkm930. Epub 2007 Dec 26.
4
Demasculinization of X chromosomes in the Drosophila genus.果蝇属X染色体的去雄性化
Nature. 2007 Nov 8;450(7167):238-41. doi: 10.1038/nature06330.
5
Constraint and turnover in sex-biased gene expression in the genus Drosophila.果蝇属性别偏向基因表达中的限制与转换
Nature. 2007 Nov 8;450(7167):233-7. doi: 10.1038/nature06323.
6
Beyond the sequence: cellular organization of genome function.超越序列：基因组功能的细胞组织
Cell. 2007 Feb 23;128(4):787-800. doi: 10.1016/j.cell.2007.01.028.
7
Non-Disjunction as Proof of the Chromosome Theory of Heredity.非分离现象作为遗传染色体学说的证据
Genetics. 1916 Jan;1(1):1-52. doi: 10.1093/genetics/1.1.1.
8
Y chromosomes: born to be destroyed.Y染色体：生来就要被破坏。
Bioessays. 2005 Oct;27(10):1076-83. doi: 10.1002/bies.20288.
9
Sex chromosomes: evolution of the weird and wonderful.
Curr Biol. 2005 Feb 22;15(4):R129-31. doi: 10.1016/j.cub.2005.02.011.
10
A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults.黑腹果蝇成虫中卵巢、睾丸和躯体偏向性基因表达的调查。
Genome Biol. 2004;5(6):R40. doi: 10.1186/gb-2004-5-6-r40. Epub 2004 Jun 1.
Zotero 插件