阿片类拮抗剂与人类海洛因自我给药行为的改变：一项实验研究。

Opiate antagonists and the modification of heroin self-administration behavior in man: an experimental study.

作者信息

Altman J L, Meyer R E, Mirin S M, McNamee H B

出版信息

Int J Addict. 1976;11(3):485-99. doi: 10.3109/10826087609056165.

Abstract

The heroin self-administration behavior of 8 inpatient heroin addicts was examined for 10 days under blocked (i.e., following ingestion of narcotic antagonists--naloxone or naltrexone) and unblocked (no antagonist) conditions. In the unblocked state, subjects injected all the available heroin, but they ceased heroin use almost completely following antagonist administration. Possible explanations for these results are discussed along with their implications for treatment.

摘要

在阻断（即摄入麻醉拮抗剂——纳洛酮或纳曲酮）和未阻断（无拮抗剂）条件下，对8名住院海洛因成瘾者的海洛因自我给药行为进行了为期10天的研究。在未阻断状态下，受试者注射了所有可得的海洛因，但在给予拮抗剂后，他们几乎完全停止了使用海洛因。文中讨论了这些结果的可能解释及其对治疗的意义。