Lin Kevin, Eradat Jilbert, Mehta Niraj H, Bent Chris, Lee Steve P, Apple Sophia K, Bassett Lawrence W
Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1041-7. doi: 10.1016/j.ijrobp.2008.02.017. Epub 2008 Apr 11.
To examine, in a retrospective study, whether the initial posttreatment mammogram offers any benefit to patients.
Patients were selected who had radiation after breast-conservation therapy from 1995 through 2005 and had follow-up mammography at the University of California-Los Angeles (UCLA) within 1 year of completing radiotherapy. Results of the initial follow-up mammogram were analyzed to determine the yield of this initial mammogram.
Between 1995 and 2005, 408 patients treated with breast-conserving therapy and radiation had follow-up mammograms at UCLA within 1 year of completion of radiation. Median age at radiation completion was 56.9 years. Median interval between radiation and the initial mammogram was 3.1 months. Ten patients were found to have suspicious findings on the initial postradiation mammogram, prompting biopsy, but only 2 were found to have recurrent cancer. None of those lesions were palpable. In both cases the recurrences were ductal carcinoma in situ. Thus, the yield of the initial postoperative mammogram as compared with physical examination findings is estimated at 0.49 recurrences detected per 100 mammograms performed (95% confidence interval 0.059-1.759).
The yield of the initial postradiation mammography at UCLA seems to be low, and only noninvasive carcinomas were found. Our data support the rationale to avoid the initial short-interval postradiation mammography and evaluate patients at 12 months.
在一项回顾性研究中，探讨治疗后首次乳房X光检查是否对患者有益。
选取1995年至2005年期间接受保乳治疗及放疗后在加利福尼亚大学洛杉矶分校（UCLA）完成放疗后1年内进行乳房X光随访检查的患者。分析首次随访乳房X光检查结果以确定此次检查的检出率。
1995年至2005年期间，408例接受保乳治疗及放疗的患者在完成放疗后1年内于UCLA进行了乳房X光随访检查。放疗结束时的中位年龄为56.9岁。放疗与首次乳房X光检查的中位间隔时间为3.1个月。10例患者在放疗后的首次乳房X光检查中发现可疑结果，需进行活检，但仅2例发现复发性癌症。这些病变均不可触及。两例复发病例均为导管原位癌。因此，与体格检查结果相比，首次术后乳房X光检查的检出率估计为每进行100次乳房X光检查可检测到0.49例复发病例（95%置信区间0.059 - 1.759）。
UCLA放疗后首次乳房X光检查的检出率似乎较低，且仅发现了非浸润性癌。我们的数据支持避免放疗后短期内进行首次乳房X光检查并在12个月时对患者进行评估的理论依据。
