强效抗肿瘤环状三萜皂苷洛巴托苷E的全合成

Total synthesis of lobatoside E, a potent antitumor cyclic triterpene saponin.

作者信息

Zhu Chunsheng, Tang Pingping, Yu Biao

机构信息

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

出版信息

J Am Chem Soc. 2008 May 7;130(18):5872-3. doi: 10.1021/ja801669r. Epub 2008 Apr 12.

DOI:10.1021/ja801669r

PMID:18407637

Abstract

Lobatoside E, a novel and complex cyclic triterpene saponin showing potent antitumor activities, has been synthesized for the first time, employing a highly modular approach. The synthesis, starting with oleanolic acid, D-glucose, D-galactose, L-arabinose, and L-rhamnose, requires a total of 73 steps, with the longest linear sequence of 31 steps and in 1.2% overall yield.

摘要

洛巴托苷E是一种新型复杂的具有强大抗肿瘤活性的环状三萜皂苷，首次采用高度模块化方法合成。该合成从齐墩果酸、D-葡萄糖、D-半乳糖、L-阿拉伯糖和L-鼠李糖开始，总共需要73步，最长线性序列为31步，总产率为1.2%。