Yarlagadda Sri G, Coca Steven G, Garg Amit X, Doshi Mona, Poggio Emilio, Marcus Richard J, Parikh Chirag R
Section of Nephrology, Yale University and VAMC, 950 Campbell Ave., Mail Code 151B, Bldg 35 A, Room 219, West Haven, CT 06516, USA.
Nephrol Dial Transplant. 2008 Sep;23(9):2995-3003. doi: 10.1093/ndt/gfn158. Epub 2008 Apr 11.
The term delayed graft function (DGF) is commonly used to describe the need for dialysis after receiving a kidney transplant. DGF increases morbidity after transplantation, prolongs hospitalization and may lead to premature graft failure. Various definitions of DGF are used in the literature without a uniformly accepted technique to identify DGF.
We performed a systematic review of the literature to identify all of the different definitions and diagnostic techniques to identify DGF.
We identified 18 unique definitions for DGF and 10 diagnostic techniques to identify DGF.
The utilization of heterogeneous clinical criteria to define DGF has certain limitations. It will lead to delayed and sometimes inaccurate diagnosis of DGF. Hence a diagnostic test that identifies DGF reliably and early is necessary. Heterogeneity, in the definitions used for DGF, hinders the evolution of a diagnostic technique to identify DGF, which requires a gold standard definition. We are in need of a new definition that is uniformly accepted across the kidney transplant community. The new definition will be helpful in promoting better communication among transplant professionals and aids in comparing clinical studies of diagnostic techniques to identify DGF and thus may facilitate clinical trials of interventions for the treatment of DGF.
移植肾功能延迟恢复（DGF）这一术语通常用于描述肾移植术后需要进行透析的情况。DGF会增加移植后的发病率，延长住院时间，并可能导致移植肾过早失功。文献中使用了各种DGF的定义，但对于识别DGF尚无统一认可的技术。
我们对文献进行了系统综述，以确定所有不同的DGF定义和诊断技术。
我们确定了18种独特的DGF定义和10种识别DGF的诊断技术。
使用异质性临床标准来定义DGF存在一定局限性。这会导致DGF的诊断延迟，有时甚至不准确。因此，需要一种能够可靠且早期识别DGF的诊断测试。DGF定义的异质性阻碍了识别DGF的诊断技术的发展，而这需要一个金标准定义。我们需要一个在肾移植界得到统一认可的新定义。新定义将有助于促进移植专业人员之间更好的沟通，并有助于比较识别DGF的诊断技术的临床研究，从而可能促进针对DGF治疗干预措施的临床试验。
