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癌症风险评估与遗传咨询过程:以遗传性乳腺癌和卵巢癌为例。

Cancer risk assessment and the genetic counseling process: using hereditary breast and ovarian cancer as an example.

作者信息

Prucka Sandra K, McIlvried Dawn E, Korf Bruce R

机构信息

Department of Genetics, University of Alabama at Birmingham, Birmingham, Ala., USA.

出版信息

Med Princ Pract. 2008;17(3):173-89. doi: 10.1159/000117790. Epub 2008 Apr 10.

Abstract

While only a small proportion of cancers can be attributed to a hereditary susceptibility, identifying high-risk individuals plays an essential role in medical management and has a significant impact on the patient as well as their immediate and extended family members. This paper aims at increasing the medical professionals' knowledge of the components of a genetic counseling session, with particular attention toward identifying at-risk individuals and understanding the complexities of the testing process. In addition, tools are provided to assist in identifying these individuals in clinical practice and streamlining the referral process to a cancer genetics center.

摘要

虽然只有一小部分癌症可归因于遗传易感性,但识别高危个体在医疗管理中起着至关重要的作用,对患者及其直系和旁系家庭成员也有重大影响。本文旨在增加医学专业人员对遗传咨询环节组成部分的了解,尤其关注识别高危个体以及理解检测过程的复杂性。此外,还提供了一些工具,以协助在临床实践中识别这些个体,并简化转诊至癌症遗传学中心的流程。

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