Aragão Ricardo Evangelista Marrocos de, Muccioli Cristina, Barrreira Ieda Maria Alexandre, Ribeiro Daniel Canamary Silveira, Timóteo Cristiane Nobrega Gularte
Universidade de Regensburg, Alemanha, Brasil.
Arq Bras Oftalmol. 2008 Jan-Feb;71(1):101-3. doi: 10.1590/s0004-27492008000100021.
Cryptococcal meningitis is caused by the yeast Cryptococcus neoformans. Two varieties are recognized: var. gattii and var. neoformans. It is usually associated with immunosuppressive states, particularly HIV infection. Cryptococcal infection of the central nervous system is uncommon in immunocompetent children and difficult to diagnose. Ocular complications are common. Optic disc swelling was found in 33%. The following report describes a case of meningitis caused by C. neoformans var. gattii in an 8 year-old immunocompetent child who developed optic atrophy. The patient was treated with amphotericin B associated with corticosteroids. Possible therapeutic strategies aimed at reducing visual loss in cryptococcal meningitis have great importance to avoid this important morbidity.
隐球菌性脑膜炎由新型隐球菌酵母引起。已确认有两个变种:格特变种和新生变种。它通常与免疫抑制状态相关,尤其是HIV感染。中枢神经系统的隐球菌感染在免疫功能正常的儿童中并不常见,且难以诊断。眼部并发症很常见。33%的患者出现视盘肿胀。以下报告描述了一例由格特变种新型隐球菌引起的脑膜炎病例,该病例发生在一名8岁免疫功能正常的儿童身上,该儿童出现了视神经萎缩。患者接受了两性霉素B联合皮质类固醇治疗。旨在减少隐球菌性脑膜炎视力丧失的可能治疗策略对于避免这种重要的发病率至关重要。