Kaciński Marek, Kubik Alicja, Herman-Sucharska Izabela, Paciorek Anna, Kroczka Sławomir, Zajac Anna
Klinika Neurologii Dziecigcej, Uniwersytetu Jagiellońskiego, Collegium Medicum, Kraków.
Przegl Lek. 2007;64(11):923-8.
Cavum septum pellucidum (CSP) is commonly known marker of neurodevelopmental brain malformation. In MR imaging it is seen either as an isolated finding or with association of others developmental brain changes e.g. cavum vergae (CV).
was to assess the frequency of CSP and CV associated with others brain developmental malformations in children. We also classified clinical syndromes in children with these structural brain malformations.
The study was performed on 55 children, hospitalised in the Department of Pediatric Neurology, Jagiellonian University in Krakow, between 1998-2006 with diagnosed CSP and/or CV in MRI. There were 29 girls and 26 boys aged 4 months-16 years old. Clinical history, clinical status and neurological findings in physical examination were main indication to perform brain MRI. MRI scans was done in SE T1, FSE T2, PD, FLAIR, IR T1 sequences, 3 and 5 mm depth, in vertical, frontal and axial surfaces, performed on 1,5 T machine Signa Horizon HiSpeed General Electric.
There were 38 children with CSP, 12 children with CSP and CV, and 5 with CV. In 18/55 children (33%) CSP was isolated, but in 37/55 children (67%) CSP was coexisted with other brain structural malformations. The average age of diagnosis in isolated CSP was 10 years old, in coexisting malformation was 5 years. In half of the children, the reason of neuroimaging was epilepsy, in this 6/18 patient with isolated CSP or CV. 58% of the study group had a normal mental development, but 35% of children with additional brain malformation and 11% of children with isolated CSP and CV were mentally retarded.
透明隔腔（CSP）是常见的神经发育性脑畸形标志物。在磁共振成像中，它可表现为孤立性发现，或与其他脑部发育改变如透明隔腔（CV）相关联。
评估儿童中CSP和CV与其他脑部发育畸形相关的频率。我们还对患有这些脑部结构畸形的儿童的临床综合征进行了分类。
该研究对1998年至2006年间在克拉科夫雅盖隆大学儿科神经科住院的55名儿童进行，这些儿童在磁共振成像中被诊断出患有CSP和/或CV。其中有29名女孩和26名男孩，年龄在4个月至16岁之间。临床病史、临床状况和体格检查中的神经学发现是进行脑部磁共振成像的主要指征。磁共振成像扫描采用SE T1、FSE T2、PD、FLAIR、IR T1序列，层厚3毫米和5毫米，在垂直、冠状和轴位面上进行，使用1.5T的通用电气Signa Horizon HiSpeed机器。
有38名儿童患有CSP，12名儿童同时患有CSP和CV，5名儿童患有CV。在18/55名儿童（33%）中，CSP是孤立性的，但在37/55名儿童（67%）中，CSP与其他脑部结构畸形共存。孤立性CSP的平均诊断年龄为10岁，合并畸形的为5岁。在一半的儿童中，神经影像学检查的原因是癫痫，其中6/18例为孤立性CSP或CV患者。研究组中58%的儿童智力发育正常，但35%的合并其他脑部畸形的儿童和11%的孤立性CSP和CV儿童存在智力发育迟缓。
