Auger N, Luo Z-C, Platt R W, Daniel M
Institut national de Santé Publique du Québec, Montréal, Québec, Canada.
J Epidemiol Community Health. 2008 May;62(5):402-9. doi: 10.1136/jech.2007.064535.
The unresolved "epidemiological paradox" concerns the association between low socioeconomic status and unexpectedly favourable birth outcomes in foreign born mothers. The "healthy migrant" effect concerns the association between foreign born status per se and birth outcomes. The epidemiological paradox and healthy migrant effect were analysed for newborns in a favourable sociopolitical environment.
98,330 live births to mothers in Montreal, Canada from 1997 to 2001 were analysed. Mothers were categorised as foreign born versus Canadian born. Outcomes were: small for gestational age (SGA) birth; low birth weight (LBW) and preterm birth (PTB). Multilevel logistic regression was used to examine the interaction between maternal education and foreign born status, adjusting for covariates.
Not having a high school diploma was associated with LBW in Canadian (odds ratio (OR) 3.20; 95% CI 2.61 to 3.91) but not foreign born (OR 1.14; 95% CI 0.99 to 2.10) mothers and was more strongly associated with SGA birth in Canadian (OR 2.03; 95% CI 1.84 to 2.22) than in foreign born (OR 1.26; 95% CI 1.07 to 1.49) mothers. Foreign born status was associated with SGA birth (OR 1.37; 95% CI 1.28 to 1.47), LBW (OR 1.51; 95% CI 1.27 to 1.79) and PTB (OR 1.12; 95% CI 1.03 to 1.22) in university-educated mothers only.
The epidemiological paradox associated with low educational attainment was present for SGA birth and LBW but not PTB. Foreign born status was associated with adverse birth outcomes in university-educated mothers, the opposite of the healthy migrant effect.
尚未解决的“流行病学悖论”涉及外国出生母亲的低社会经济地位与意外良好的出生结局之间的关联。“健康移民”效应涉及外国出生身份本身与出生结局之间的关联。在有利的社会政治环境中对新生儿的流行病学悖论和健康移民效应进行了分析。
对1997年至2001年加拿大蒙特利尔市98330例母亲的活产情况进行了分析。母亲被分为外国出生和加拿大出生两类。结局指标包括:小于胎龄(SGA)出生;低出生体重(LBW)和早产(PTB)。采用多水平逻辑回归分析母亲教育程度与外国出生身份之间的相互作用,并对协变量进行了调整。
未获得高中文凭与加拿大出生母亲的低出生体重相关(优势比(OR)3.20;95%可信区间2.61至3.91),但与外国出生母亲无关(OR 1.14;95%可信区间0.99至2.10),且与加拿大出生母亲的小于胎龄出生关联更强(OR 2.03;95%可信区间1.84至2.22),而外国出生母亲为(OR 1.26;95%可信区间1.07至1.49)。仅在受过大学教育的母亲中,外国出生身份与小于胎龄出生(OR 1.37;95%可信区间1.28至1.47)、低出生体重(OR 1.51;95%可信区间1.27至1.79)和早产(OR 1.12;95%可信区间1.03至1.22)相关。
与低教育程度相关的流行病学悖论在小于胎龄出生和低出生体重方面存在,但早产方面不存在。外国出生身份与受过大学教育母亲的不良出生结局相关,与健康移民效应相反。