Okuda Takeshi, Akai Fumiharu, Kataoka Kazuo, Taneda Mamoru
Department of Neurosurgery, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Brain Tumor Pathol. 2008;25(1):33-8. doi: 10.1007/s10014-007-0227-z. Epub 2008 Apr 16.
Lymphomatoid granulomatosis (LYG) is a systemic granulomatous disease characterized by B-cell proliferation of uncertain malignant potential. It most frequently affects the lungs but also occasionally affects the central nervous system. Its pathophysiology is unclear in numerous respects, thus making it difficult to diagnose and treat. We recently encountered a case of LYG that was followed clinically and histologically for 14 months. A 55-year-old man was hospitalized with multiple brain tumors for which the final diagnosis was not made until the second surgery, 14 months after the first intervention. Following the diagnosis, he was treated with steroid pulse therapy. At present, 3.5 years after the onset of LYG, the patient is in good condition with no signs of tumor recurrence. Although LYG is usually graded on the basis of histological findings, this patient showed no histological changes or any increase in disease grade during the 14-month follow-up period.
淋巴瘤样肉芽肿病（LYG）是一种系统性肉芽肿性疾病，其特征为具有不确定恶性潜能的B细胞增殖。它最常累及肺部，但偶尔也会累及中枢神经系统。其病理生理学在许多方面尚不清楚，因此难以诊断和治疗。我们最近遇到一例淋巴瘤样肉芽肿病患者，对其进行了为期14个月的临床和组织学随访。一名55岁男性因多发性脑肿瘤住院，直到首次干预14个月后的第二次手术才做出最终诊断。确诊后，他接受了类固醇冲击疗法治疗。目前，淋巴瘤样肉芽肿病发病3.5年后，患者状况良好，无肿瘤复发迹象。尽管淋巴瘤样肉芽肿病通常根据组织学结果分级，但该患者在14个月的随访期内未出现组织学变化或疾病分级的任何增加。
