使用含有不透射线标志物的缓释胶囊测量结肠运输时间。
Measurement of colonic transit using a delayed-release capsule containing radio-opaque markers.
作者信息
Park Jae Myung, Choi Myung-Gyu, Choi Hwang, Cho Yu Kyung, Oh Jung Hwan, Lee In Seok, Kim Sang Woo, Choi Kyu Yong, Chung In-Sik
机构信息
Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
Scand J Gastroenterol. 2008;43(5):545-50. doi: 10.1080/00365520701850204.
OBJECTIVE
Colonic transit scintigraphy has several advantages in comparison with radio-opaque marker (ROM) techniques but it is limited to specialized centers. The aim of the study was to validate the ROM technique for measuring colonic transit using delayed-release capsules.
MATERIAL AND METHODS
Colonic transit is expressed as the sum of the weighted mean marker residence times in the colon (geometric centers). Delayed-release capsules containing radio-opaque markers (DC-ROMs) or scintigraphic methods were compared simultaneously in 10 healthy volunteers. Reproducibility and responsiveness of DC-ROM measurements were evaluated in 10 healthy volunteers at an interval of 2 weeks and after bisacodyl treatment, respectively.
RESULTS
The transit profiles between the scintigraphic and DC-ROM methods were highly correlated (r = 0.994, p < 0.01). The reproducibility and responsiveness of DC-ROM measurements were good. Colonic transit measured by DC-ROM correlated with the stool form scale (r = 0.66, p < 0.01).
CONCLUSION
The DC-ROM test is simple, highly reproducible, responsive, and appropriate for clinical trials and clinical practice.
目的
与不透X线标志物（ROM）技术相比，结肠运输闪烁扫描术有多个优点，但它仅限于专业中心使用。本研究的目的是验证使用缓释胶囊测量结肠运输的ROM技术。
材料与方法
结肠运输表示为结肠（几何中心）中加权平均标志物停留时间的总和。在10名健康志愿者中同时比较了含有不透X线标志物的缓释胶囊（DC-ROM）和闪烁扫描法。分别在10名健康志愿者中每隔2周以及在比沙可啶治疗后评估DC-ROM测量的可重复性和反应性。
结果
闪烁扫描法和DC-ROM法之间的运输曲线高度相关（r = 0.994，p < 0.01）。DC-ROM测量的可重复性和反应性良好。通过DC-ROM测量的结肠运输与粪便形态量表相关（r = 0.66，p < 0.01）。
结论
DC-ROM试验简单、高度可重复、有反应性，适用于临床试验和临床实践。
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