Schindlbeck N E, Klauser A G, Müller-Lissner S A
Abteilung für Gastroenterologie, Medizinische Klinik, Klinikum Innenstadt der Universität München.
Z Gastroenterol. 1990 Aug;28(8):399-404.
Several methods have been described to measure colonic transit times. The physical properties of all types of markers used allow to analyze and quantify them in stool samples or in the colon. The selective measurement of colonic (ceco-anal) transit time requires complicated intubation techniques. For most purposes it is sufficient to approximate the colonic transit by the whole gut transit, since oro-cecal transit time usually is only about a tenth of whole gut transit time. For this purpose the marker can be administered orally. In order to measure segmental colonic transit times it is necessary to monitor the distribution of the markers within the colon. For that purpose scintigraphic techniques are suited, but they require special equipment and are time consuming. Radio-opaque pellets, in contrast, are cheap, easy to handle, and have no known side effects. The following procedure is recommended: the patient swallows a gelatin capsule which contains 20 radio-opaque pellets on each of 6 consecutive days at the same time when on day seven a single abdominal x-ray is obtained. Then, segmental and total colonic transit times can be calculated from the number of retained pellets.
已经描述了几种测量结肠运输时间的方法。所使用的所有类型标记物的物理特性使得能够在粪便样本或结肠中对它们进行分析和量化。结肠（盲肠至肛门）运输时间的选择性测量需要复杂的插管技术。对于大多数目的而言，通过全肠道运输来近似结肠运输就足够了，因为口盲肠运输时间通常仅约为全肠道运输时间的十分之一。为此，可以口服标记物。为了测量节段性结肠运输时间，有必要监测标记物在结肠内的分布。为此，闪烁扫描技术是合适的，但它们需要特殊设备且耗时。相比之下，不透射线的药丸价格便宜、易于操作且没有已知的副作用。建议采用以下程序：患者在连续6天的同一时间每天吞下一粒含有20颗不透射线药丸的明胶胶囊，在第7天进行一次腹部X光检查。然后，可以根据留存药丸的数量计算节段性和总的结肠运输时间。
